反应详情

温度

90 °C

To a solution of 3-bromothiophene-2-carboxaldehyde (2.0 g) and 3-trifluoromethylbenzene boronic acid (2.19 g) in ethylene glycol dimethyl ether (100 ml) was added sodium carbonate (2.9 g), tetrakis(triphenylphosphine) palladium (0) (0.12 g) and water (50 ml). The mixture was heated to 90° C. under nitrogen. After 18 hours the reaction was allowed to cool and was concentrated. The residue was partitioned between water and ethyl acetate; the organic solution was taken and was washed with brine and then dried (MgSO4) and concentrated. The crude material was purified by SPE (Si); the product eluted with neat chloroform to furnish the title compound as a yellow solid.

1. temperatureto cool
2. concentrationwas concentrated
3. customThe residue was partitioned between water and ethyl acetate
4. washwas washed with brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. customThe crude material was purified by SPE (Si)
8. washthe product eluted with neat chloroform