HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azide → HCID 131720714, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azide | HCID 33558 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-2-Acetamido-3-(4-cyanophenyl)propanoic acid | HCID 11085640 | — |
| Reactant | HCID 131720713 | HCID 131720713 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131720714 | HCID 131720714 | 82.4% |
Reaction Steps
Stir overnight H-(L)-Chg-(L)-Pal-NH2.2HCl (1.13 g, 3 mmol), Ac-(L)Phe(4-CN)-OH (0.84 g, 3.6 mmol), diisopropylethylamine (10 mmol). and diphenylphoshoryl azide (803 μl 3.6 mmol) dimethyl formamide (30 mL) overnight. Evaporate dimethyl formamide, precipitate by ether, filter and wash by ether to give Ac-(L)-Phe(4-CN)-(L)-Chg-(L)-Pal-NH2 (1.282 g, 82%). ##STR21##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05766932 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-a0bf2bac88774984b038ae288f88a234 |
| Source note | uspto-grants-1998_06 |