Sodium Carbonate → HCID 19079042, compound

HRID 963984Notes

Reaction equation

HRID 963984 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH2:15])[CH2:10][CH2:9]1.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)CCO>[N:3]1[CH:4]=[CH:5][N:6]=[CH:7][C:2]=1[N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH2:15])[CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 73277Chloropyrazine

Product 1

HCID 19079042HCID 19079042, compoundYield 67.5%

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of chloropyrazine (14.3 g), 1-(piperid-4-yl)methylamine (14.25 g), sodium carbonate (11.4 g) and 3-methyl-1-butanol (100 ml) was stirred and heated under reflux for 64 hours, cooled to ambient temperature and filtered. The solvent was removed in vacuo and the residual oil was distilled to give 1-[1-(pyrazin-2-yl)piperid-4-yl]methylamine as a pale yellow oil (16.2 g), b.p. 136°-160° C. at 0.6 mbar.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 64 hours
  3. filtrationfiltered
  4. customThe solvent was removed in vacuo
  5. distillationthe residual oil was distilled

Sources & evidence

ORD record
ord-21f4cd5086e14c23ba4a20a260c64470
Source dataset
uspto-grants-1998_06
Patent number
US05767116

Reaction notes

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