反应详情

A mixture of 4-carbamoyl-1-(2,4-dinitrophenyl)-pyridinium chloride (13.6 g), 2-methoxyaniline (10 ml) and methanol (500 ml) was stirred at ambient temperature for 16 hours and the solvent was removed in vacuo. Ether containing a small amount of acetone was added and the mixture heated under reflux until solidification of the product was complete. The product was collected by filtration to give 4-carbamoyl-1-(2-methoxyphenyl)-pyridinium chloride as a yellow solid (11.5 g), m.p. 229°-230° C. (dec).

1. customthe solvent was removed in vacuo
2. additionEther containing a small amount of acetone was added
3. temperaturethe mixture heated
4. temperatureunder reflux until solidification of the product
5. filtrationThe product was collected by filtration