反应详情

A mixture of 4-carbamoyl-1-phenylpyridinium chloride (13 g), 10% palladium-on-carbon catalyst (260 mg) and ethanol (250 ml) was hydrogenated at ambient temperature and pressure for 2 days. The solution was filtered (Celite) and the filtrate was concentrated to approximately 50 ml. This solution was cooled and the solid precipitate collected by filtration to give 1-phenylpiperidine-4-carboxamide (5.99 g).

1. customwas hydrogenated at ambient temperature
2. filtrationThe solution was filtered (Celite)
3. concentrationthe filtrate was concentrated to approximately 50 ml
4. temperatureThis solution was cooled
5. filtrationthe solid precipitate collected by filtration