反应详情

A suspension of 4-carbamoyl-1-(3-methoxyphenyl)-pyridinium chloride (26 g) in methanol (300 ml) was hydrogenated at ambient temperature and pressure in the presence of 10% palladium-on-carbon catalyst (2.0 g) until hydrogen uptake ceased (~2 days) The mixture was filtered, excess triethylamine added and the solvent removed in vacuo to give a pink solid. This was partitioned between water and chloroform. The organic phase was dried and the solvent removed in vacuo to give 1-(3-methoxyphenyl)piperidine-4-carboxamide as a pink solid (19 g), m.p. 153°-156° C.

1. customwas hydrogenated at ambient temperature
2. custom(~2 days)
3. filtrationwas filtered
4. additionexcess triethylamine added
5. customthe solvent removed in vacuo
6. customto give a pink solid
7. customThis was partitioned between water and chloroform
8. customThe organic phase was dried
9. customthe solvent removed in vacuo