Acetic Acid → HCID 10572092, compound

Participants

Reaction Steps

A solution of potassium hydroxide (1. 0 g) in water (19.7 ml) and ethanol (19.7 ml) was added in portions (~10 ml) at 15 minute intervals to [2-({[1-(2-methoxyphenyl)piperid-4-yl]methylamino}methyl)-1,4-benzodioxan-8-yl]toluene-4-sulphonate dihydrochloride (0.15 g). The mixture was heated under reflux for 21/2 hours, cooled and neutralised with glacial acetic acid. The product was extracted into ether (3×100 ml) and the combined extracts allowed to stand for 16 hours. The precipitate which had then formed was collected by filtration and dried to give N-(8-hydroxy-1,4-benzodioxan-2-ylmethyl) -1-[1-(2-methoxyphenyl) piperid-4-yl]methylamine as a colourless solid (0.2 g), m.p. 116°-119° C.

Provenance & Evidence