6-bromo-3-benzyloxazolo[4,5-b]pyridin-2(3H)-one → HCID 15379437, compound

HRID 964017Notes

Reaction equation

HRID 964017 reaction equation
Br[C:2]1[CH:3]=[C:4]2[O:10][C:9](=[O:11])[N:8]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:5]2=[N:6][CH:7]=1.BrC1[CH:21]=[C:22]2[O:28]C(=O)N(C)C2=NC=1>>[CH2:12]([N:8]1[C:5]2=[N:6][CH:7]=[C:2]([C:22](=[O:28])[CH3:21])[CH:3]=[C:4]2[O:10][C:9]1=[O:11])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 136144686-bromo-3-benzyloxazolo[4,5-b]pyridin-2(3H)-oneHCID 159260166-Bromo-3-methyl[1,3]oxazolo[4,5-b]pyridin-2(3H)-one

Product 1

HCID 15379437HCID 15379437, compound

Procedure

The method of operation is the same as that used for the synthesis of the compound of Example 1 (coupling with 1-ethoxy-1-(trimethylstannyl)ethylene), 6-bromo-3-benzyloxazolo[4,5-b]pyridin-2(3H)-one from Preparation 13 being used instead of 6-bromo-3-methyloxazolo[4,5-b]pyridin-2(3H)-one. The yield obtained is 75%. ##STR47##

Workup

  1. customThe yield obtained

Sources & evidence

ORD record
ord-4e0c3ae897964fd298ebf6bbcd22aa39
Source dataset
uspto-grants-1998_06
Patent number
US05767128

Reaction notes

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