HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 15511889, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-(2-hydroxyphenyl)propanal | HCID 10419351 | — |
| Reactant | 1-(3,4-dihydro-2H-1-benzopyran-2-yl)methanamine | HCID 11263686 | — |
| Reactant | HCID 19079509 | HCID 19079509 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15511889 | HCID 15511889 | — |
Reaction Steps
A solution of 2.8 g 2-aminomethyl-chromane [obtainable by reacting 3-(2-hydroxy-phenyl)-propanal with KCN and subsequent catalytic reduction of the 2-cyano-chromane] and 2.2 g 3-chloromethyl)-pyridine in 250 ml of DMF are stirred together with 1 g N-methyl-morpholine for 12 hours at 20° and worked up in a conventional manner to give N-(3-pyridylmethyl)-N-(2-chromanyl-methyl)-amine. Stirring with 0.5 equivalents of maleic acid in 100 ml ethanol gives the maleate, m.p 163°-164°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05767132 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-69522862dc4e4c2983a788c91b6bc58e |
| Source note | uspto-grants-1998_06 |