Oxalic Acid → HCID 87238501, compound

HRID 964049Notes

Reaction equation

HRID 964049 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3]>C(O)C.O>[OH2:3].[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3]

Participants

3

Reactant 1

HCID 971Oxalic Acid

Product 1

HCID 87238501HCID 87238501, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

Analogously to Example 7 a solution of 2.3 g sodium phenolate and 2.5 g N-3-chloropropyl-N-[5-(4-fluorophenyl)-3-pyridylmethyl]-amine [obtainable by reaction of 3-hydroxypropylamine with 3-chloromethyl-5-(4-fluorophenyl)-pyridine and subsequent transformation of the product to the 3-chloropropyl-compound by reaction with PCl3 ] in 200 ml of acetonitrile is stirred for 5 hours at room temperature and worked up in a conventional manner to give N-(3-phenoxy-propyl)-N-[5-(4-fluorophenyl)-3-pyridyl-methyl]-amine. Stirring with Q5 equivalents of oxalic acid in 100 ml ethanol/water mixture gives the oxalate-hemihydrate, m.p. 217°.

Sources & evidence

ORD record
ord-8d963b9d660c4eba8c897e732f901d24
Source dataset
uspto-grants-1998_06
Patent number
US05767132

Reaction notes

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