Ethyl Acetate → 4-(3-Aminopropoxy)pyridine

Participants

Reaction Steps

Hydrazine monohydrate [2.99 ml (61.6 mmol)) was added to a suspension of 5.80 g (20.5 mol) of 4-(3-phthalimidopropyloxy)pyridine in 50 ml of ethanol, and the mixture was stirred at room temperature for 3 hours. 100 ml of ethyl acetate was added and insoluble materials were filtered off. The volatile component in the filtrate was distilled off and then chloroform was added to the residue: The mixture was washed with brine and dried over potassium carbonate. The solvent was distilled off to obtain 2.99 g of the desired-compound (yield: 99.5%, pale yellow oil).

Provenance & Evidence