反应详情

To a solution of 4.01 g (14.8 mmol) of 4-(phthalimidomethylthio)pyridine in 25 ml of methanol, a solution of 1.08 g (29.7 mmol) of sodium borohydride in 20 ml of methanol was added. The mixture was stirred at room temperature for 4 hours. Glacial acetic acid (0.5 ml) was added to quench the reaction, and then the solvent was distilled off. The residue was dissolved in chloroform, washed with water and dried, and the solvent was distilled off. The residue was purified by recrystallization (recrystallization solvent: ethanol) to obtain 2.35 g of the desired compound (yield: 58.3%, yellow crystals).

1. customto quench
2. customthe reaction
3. distillationthe solvent was distilled off
4. dissolutionThe residue was dissolved in chloroform
5. washwashed with water
6. customdried
7. distillationthe solvent was distilled off
8. customThe residue was purified by recrystallization (recrystallization solvent: ethanol)