1-Naphthalenesulfonyl chloride → 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide

HRID 96414Notes

Reaction equation

HRID 96414 reaction equation
[CH2:1]1[NH:2][CH2:3][CH2:4][c:5]2[cH:6][c:7]([NH:11][C:12](=[O:13])[c:14]3[c:15](-[c:20]4[cH:21][cH:22][c:23]([C:26]([F:27])([F:28])[F:29])[cH:24][cH:25]4)[cH:16][cH:17][cH:18][cH:19]3)[cH:8][cH:9][c:10]21.[c:30]1([S:40](=[O:41])(=[O:42])[Cl:43])[cH:31][cH:32][cH:33][c:34]2[cH:35][cH:36][cH:37][cH:38][c:39]12>>[CH2:1]1[N:2]([S:40]([c:30]2[cH:31][cH:32][cH:33][c:34]3[cH:35][cH:36][cH:37][cH:38][c:39]23)(=[O:41])=[O:42])[CH2:3][CH2:4][c:5]2[cH:6][c:7]([NH:11][C:12](=[O:13])[c:14]3[c:15](-[c:20]4[cH:21][cH:22][c:23]([C:26]([F:27])([F:28])[F:29])[cH:24][cH:25]4)[cH:16][cH:17][cH:18][cH:19]3)[cH:8][cH:9][c:10]21

Participants

3

Reactant 2

HCID 665601-Naphthalenesulfonyl chlorideHCID 110147584'-Trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4tetrahydroisoquinolin-6-yl)-amide

Product 1

HCID 154342594'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide

Sources & evidence

ORD record
ord-26a94aaf5bfc42a18e520c7e336ab472
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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