Formic acid methanol → 3-(2-Cyanoethoxy)carbonyl-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl) pyridine-5-carboxylic acid

HRID 964271Notes

Reaction equation

HRID 964271 reaction equation
C([O:8][C:9]([C:11]1[CH:16]([C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:18]=2[N+]([O-])=O)[C:15]([C:29]([O:31][CH2:32][CH2:33][C:34]#[N:35])=[O:30])=[C:14]([CH3:36])[NH:13][C:12]=1[CH3:37])=[O:10])C1C=CC=CC=1.C(O)=O.CO>C(Cl)(Cl)Cl.[Pd]>[C:34]([CH2:33][CH2:32][O:31][C:29]([C:15]1[CH:16]([C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)[C:11]([C:9]([OH:10])=[O:8])=[C:12]([CH3:37])[NH:13][C:14]=1[CH3:36])=[O:30])#[N:35]

Participants

5

Reactant 2

HCID 18963719Formic acid methanolHCID 19079341HCID 19079341, compound

Product 1

HCID 104994373-(2-Cyanoethoxy)carbonyl-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl) pyridine-5-carboxylic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6212ChloroformSolvent

Procedure

The solution of 3-benzyloxycarbonyl-5-(2-cyanoethoxy)carbonyl-1,4-dihydro-2,6-dimethyl-4-(4-nitronitrophenyl)pyridine (3.24 g, 7.02 mmol) in 160ml of 4.4% (w/w) formic acid/MeOH mixture was stirred with Pd/C (10%, 3.24 g) for 30 min., the reaction was quenched by addition of 10 ml of CHCl3. The mixture was filtered and concentration of filtrate give a yellow powder, which was dissolved in CHCl3, washed with water and 1N HCL. After drying and removal of solvent, 3-(2-cyanoethoxy)carbonyl-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine-5-carboxylic acid was obtained as a yellow powder (1.94 g, 75%)

Workup

  1. customthe reaction was quenched by addition of 10 ml of CHCl3
  2. filtrationThe mixture was filtered
  3. customconcentration of filtrate give a yellow powder, which
  4. washwashed with water and 1N HCL
  5. customAfter drying
  6. customremoval of solvent

Sources & evidence

ORD record
ord-8a613bfeaf624cbe87ac79096008bc10
Source dataset
uspto-grants-1998_06
Patent number
US05767131

Reaction notes

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