HCID 86752798, compound → HCID 86752796, compound

Participants

Reaction Steps

A solution of 200 mg of biphenyl-4,4'-dicarboxylic acid bis-[[benzyl 2,6-didesoxy-3,4-di-O-sulfo-6-(2,3,4,5,6-penta-O-sulfo-D-gluconoylamino)-α-D-glucopyranosid-2-yl]-amide] tetradecasodium salt (see Ex. 14.F.) in 12 ml of 2N sodium hydroxide was left at room temperature for 8 hours, neutralized with acidic ion exchanger (Amberlite IR 120 H+) and concentrated. The residue was chromatographed over Sephadex C25 Na+) with water and gave biphenyl-4,4'-dicarboxylic acid bis-[[(Z)-benzyl 2,6-didesoxy-3,4-di-O-sulfo-6-(3-desoxy-2,4,5,6-tetra-O-sulfo-D-erythro-hex-2-enonoylamino)-α-D-glucopyranosid-2-yl]-amide] dodecasodium salt, [α]+67.50 (c 0.2; water), MS: m/z 2288 (reconstructed M).

Provenance & Evidence