Ethanol → HCID 11749254, compound

Participants

Reaction Conditions

Reaction Steps

To 100 mg of 5-chloro-2-pivaloylamino-2,3-dimethoxybenzophenone were added 2 ml of ethanol and 0.1 ml of tetrahydrofuran and the mixture was warmed to about 40° C. for dissolution. After the solution was cooled to 25° C., 29 mg of sodium borohydride was added and the reaction was carried out with stirring at 25°-33° C. for 5 hours. The reaction mixture was diluted with 0.1 ml of water and distilled under reduced pressure. The residue was dissolved in 1 mL of methylene chloride and the solution was washed with 1 L of water and distilled under reduced pressure. The residue was dissolved in 0.2 L of methylene chloride followed by addition of 2 mL of n-hexane, whereupon white crystals separated out. The crystals were harvested by filtration, washed with 0.5 mL of n-hexane, and dried under reduced pressure to provide 90.4 mg of 5-chloro-2-pivaloylamino-α-(2',3'-dimethoxyphenyl)benzyl alcohol. Yield 90%.

Provenance & Evidence