反应详情

温度

20 °C

A solution prepared by dissolving 29.5 g, of 2,3-dimethoxycarbonylpyridine in 200 ml of ethylether was added dropwise to a solution prepared by suspending 10 g of lithium aluminum hydride in 300 ml of dried ethylether at 0° C. This mixed solution was stirred at 20° C. for 3 hours and 30 ml of water was slowly added thereto at 0° C. The resulting solution was stirred for 5 hours at the room temperature and solid was filtered through celite. The filtrate was evaporated under reduced pressure and then the residual product was purified by a silica gel column chromatography (chloroform : methanol (10:1)) to give 10.4 g of the above title compound (yield: 75%).

1. customA solution prepared
2. dissolutionby dissolving 29.5 g
3. customprepared
4. customat 0° C
5. customat 0° C
6. stirringThe resulting solution was stirred for 5 hours at the room temperature and solid
7. filtrationwas filtered through celite
8. customThe filtrate was evaporated under reduced pressure
9. customthe residual product was purified by a silica gel column chromatography (chloroform : methanol (10:1))