Water → HCID 23435624, compound

Participants

Reaction Steps

A solution of 1-(13-tetradecenyl)-3,7-dimethylxanthine (2.00 g, 5.35 mmol), 4-methylmorpholine-N-oxide (2.72 ml, 60% wt. in water, 15.8 mmol) and potassium osmate dihydrate (21 mg, 0.05 mmol) in acetone/water, in a ratio of 3:1 (80 mL), was stirred for 16 hours. Water (100 ml) and sodium sulfite (1 g) were added and stirred for 1 hour. The reaction mixture was extracted with dichloromethane (3×100 ml) and the organic phase dried over magnesium sulfate. The solvent was evaporated to obtain 2.1 g of 1-(13,14-dihydroxytetradecyl)-3,7-dimethylxanthine as a white solid (96% yield).

Provenance & Evidence