Hydrochloric Acid → 1-(16-Hydroxyheptadecyl)-3,7-dimethylxanthine

Participants

Reaction Conditions

Reaction Steps

0.25 g of 1-(16,17-oxidoheptadecyl)-3,7-dimethylxanthine (0.58 mmol) was dissolved in ethanol (5 ml). Sodium borohydride (0.34 g, 0.93 mmol) was added to the ethanol solution and the reaction stirred at 60° C. for 16 hours. Hydrochloric acid (1.0M, 10 ml) was added and extracted with dichloromethane (2×30 ml). The combined extracts were dried over magnesium sulfate. Evaporated solvent left 0.225 g of 1-(16-hydroxyheptadecyl)-3,7-dimethylxanthine as a white solid (90% yield).

Provenance & Evidence