Sulfuric Acid → 6,7-Dimethoxy-4-(3,4-dimethoxyphenyl)-2-methylquinoline-3-carboxylic acid propyl ester

Participants

Reaction Steps

To a mixture of 2-amino-4,5,3',4'-tetramethoxybenzophenone, propyl acetoacetate and acetic acid, concentratd sulfuric acid was added, followed by the same treatment as in Reference Example 1, to yield 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-methylquinoline-3-carboxylic acid propyl ester (79%), which was then recrystallized from ethyl acetate-isopropyl ether to yield a colorless prismatic crystal having a melting point of 153° to 155° C.

Provenance & Evidence