Hydrochloric Acid → HCID 19077582, compound

Participants

Reaction Steps

28% sodium methoxide--methanol solution (1.16 g) was added to (E)-2-[2-(6-chloropyridin-2-yloxymethyl)phenyl]-2-methoxyimino-N-methylacetamide (400 mg), and the mixture was heated under reflux with stirring for 4 hours. The mixture was neutralized with 1N hydrochloric acid, and water was added. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried, and the solvent was evaporated. The resulting oil was purified by column chromatography on silica gel to give the title compound (61 mg). mp. 81°-82° C.

Provenance & Evidence