Water → HCID 140391174, compound

Participants

Reaction Steps

2-[2-(3,5-dimethylphenoxy)phenyl]-2-oxo-N-methyl-acetamide (2.58 g) and methoxylamine hydrochloride (1.52 g) were dissolved in methanol (50 ml), and the mixture was heated under reflux with stirring overnight. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried, and then the solvent was evaporated. The resulting oil was purified by column chromatography on silica gel to give the title compound (1.96 g). mp. 90°-91° C.

Provenance & Evidence