Hydrochloric Acid → HCID 67232787, compound

Participants

Reaction Conditions

Reaction Steps

HCl gas was bubbled through a solution of (S)-α-amino-4-methoxy-α-methyl-benzeneacetic acid, hydrochloride salt (2.0 g, 8.6 mmol) in EtOH (25 mL) at 4° C. The solution was stirred for 1 hour at 20° C. before being refluxed for 5 hours. After cooling, the solution was concentrated in vacuo. The resulting oil was dissolved in CH2Cl2, and washed with aq. NaHCO3 ; the aqueous phase was back-extracted with CH2Cl2. The combined organic fractions were washed with H2O, brine and dried over Na2SO4 prior to concentration to yield the title compound as a yellow oil (1.75 g, 91%).

Provenance & Evidence