HCID 86752822, compound → HCID 67701182, compound

Participants

Reaction Steps

A solution of (R), (S)-α-[[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-2-[4-phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-4-methoxy-benzeneacetic acid (4.04 g, 6.5 mmol) in MeOH (50 mL) containing 0.42 g of 10% Pd/C was sparged with H2 at 20° C. By TLC (10% MeOH/CH2Cl2), the reaction was complete after 40 minutes whereupon the reaction mixture was filtered and concentrated in vacuo to obtain 3.8 g of the title compound as a solid foam.

Provenance & Evidence