1-Propanol → HCID 43309296, compound

Participants

Reaction Steps

Following the procedure described in part E of Example 1 (R), (S)-α-[[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-4-methoxybenzeneacetic acid was condensed with 3-aminophenylcarbamic acid, propyl ester to generate the title compound. The 3-aminophenylcarbamic acid, propyl ester was prepared by sequentially treating commercial 3-nitrophenyl isocyanate with PrOH containing Et3N at 80° C. for 12 hours followed by reduction with Na2S2O4 in THF/H2O at 100° C.

Provenance & Evidence