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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 964634Generated: October 31, 2026

4-Aminophenol → 4-[2-(Dimethylamino)ethoxy]aniline

https://huagongshe.com/reaction/964634

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-AminophenolHCID 403—
Reactant2-(Dimethylamino)ethanolHCID 7902—
ReactantDiethyl azodicarboxylateHCID 5462977—
SolventTetrahydrofuranHCID 8028—
Product4-[2-(Dimethylamino)ethoxy]anilineHCID 6484655—

Reaction Steps

Following the procedure described in part E of Example 1 (R), (S)-α-[[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-4-methoxybenzeneacetic acid was condensed with 4-[2-(dimethylamino)ethoxy]aniline to generate the title compound. The 4-[2-(dimethylamino)ethoxy]aniline was prepared by treating commercial 4-aminophenol with DEAD, φ3P, and 2-(dimethylamino)ethanol in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05770615
Source datasetuspto-grants-1998_06
ORD IDord-9567b5c0e3414b29be3b082fe5caf6b6
Source noteuspto-grants-1998_06