反应详情

10 gm of 1-acetylamino-tetraline was dissolved into a mixed solvent of 400 ml acetone and 40 ml of 15% aqueous solution of magnesium sulfate. The solution was kept at 0° C. to add 42 gm of potassium permanganate, followed by stirring for 20 minutes at the same temperature. 800 ml of water was added to the residue obtained by concentrating the solvent. Precipitates thus obtained was extracted with chloroform and the extract was washed with brine and dried over magnesium sulfate. The residue obtained by the concentration of the solvent was subjected to silica gel column chromatography using chloroform as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 5.46 gm of the title compound.

1. customwas kept at 0° C.
2. customobtained
3. concentrationby concentrating the solvent
4. customPrecipitates thus
5. customobtained
6. extractionwas extracted with chloroform
7. washthe extract was washed with brine
8. dry with materialdried over magnesium sulfate
9. customThe residue obtained by the concentration of the solvent
10. customto obtain fractions
11. additioncontaining the target compound
12. concentrationThe fractions were concentrated