反应详情

温度

0 °C

15 gm of 2-fluorocinnamic acid was suspended into 100 ml of methanol. While maintaining the suspension at 0° C., 1.7 gm of thionyl chloride was added slowly. After the addition, the mixture was stirred for 30 minutes at 0° C. and for 4 hour at room temperature. The residue obtained by the removal of the solvent was subjected to silica gel column chromatography using chloroform as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 17.8 gm of the title compound.

1. additionAfter the addition
2. customThe residue obtained by the removal of the solvent
3. customto obtain fractions
4. additioncontaining the target compound
5. concentrationThe fractions were concentrated