2-Propenoic acid, 3-(2-fluorophenyl)-, methyl ester → Methyl 3-(2-fluorophenyl)propanoate

HRID 964651Notes

Reaction equation

HRID 964651 reaction equation
[F:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH3:9])=[O:7]>CO.[Pd]>[F:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7]

Participants

4

Reactant 1

HCID 14816712-Propenoic acid, 3-(2-fluorophenyl)-, methyl ester

Product 1

HCID 15479441Methyl 3-(2-fluorophenyl)propanoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

17.8 gm of the compound prepared in (1) above was dissolved in 200 ml of methanol. The mixture was catalytically hydrogenated using 6 gm of 10% palladium-on-carbon as a catalyst. After the removal of the catalyst by filtration and the solvent was evaporated to produce 14.7 gm of the title compound.

Workup

  1. customAfter the removal of the catalyst
  2. filtrationby filtration
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-f628515fee1f40ba976f08b4b9dd9fd9
Source dataset
uspto-grants-1998_06
Patent number
US05770605

Reaction notes

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