反应详情

The compound obtained in (3) above (380 mg) was dissolved in a mixed solvent of 5 ml of acetic acid and 10 ml of acetic anhydride. Upon the addition of 60 mg of 10% palladium-on-carbon, the mixture was catalytically hydrogenated. The catalyst was removed by filtration, the solvent was evaporated, and the residue was subjected to silica gel column chromatography using a chloroform-methanol (10:1) mixed solvent as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 90 mg of the title compound.

1. customThe catalyst was removed by filtration
2. customthe solvent was evaporated
3. additionmixed solvent as an eluant
4. customto obtain fractions
5. additioncontaining the target compound
6. concentrationThe fractions were concentrated