Hydrochloric Acid → HCID 178459249, compound

Participants

Reaction Steps

A solution of benzyl 2(R)-[(4-methoxybenzenesulfonyl)(4-picolyl)amino]-2-(trans-4-propoxycyclohexyl)-acetate (3.0 g, 5 mmol) in ethanol (50 mL) containing 3 N hydrochloric acid (5 mL, 15 mmol) is hydrogenated at 50 psi in the presence of 5% palladium on charcoal (200 mg) at room temperature for 4 hours. The reaction mixture is filtered through celite washing with ethanol and concentrated in vacuo to provide 2(R)-[(4-methoxybenzenesulfonyl)(4-picolyl)amino]-2-(trans-4-propoxycyclohexyl) acetic acid hydrochloride as a crude product.

Provenance & Evidence