Pyridine → HCID 67661077, compound

Participants

Reaction Steps

Trifluoroacetic anhydride (441 mg, 210 mmol, 296 μL) was added to a solution of trans-7-chloro-5-(naphthalen-1-yl)-1-neopentyl-1,2,3,5-tetrahydro-2-oxo-4,1-benzothiazepine-3-acetamide (98 mg, 210μmol) and pyridine (2.1 mL) at 0° C. After 1.5 h, the reaction mixture was diluted with ether, washed with water (2×) and 0.5 N aqueous hydrochloric acid, dried over anhydrous sodium sulfate, concentrated under reduced pressure and purified by flash column chromatography (methylene chloride) to give 88 mg (93%) of the title compound as a white solid.

Provenance & Evidence