Butylamine → MLS000738021

HRID 964849Notes

Reaction equation

HRID 964849 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[CH2:10]([NH2:14])[CH2:11][CH2:12][CH3:13]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([NH:14][CH2:10][CH2:11][CH2:12][CH3:13])[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

4

Reactant 2

HCID 8007ButylamineHCID 655222-Amino-4,6-dichloropyrimidine

Product 1

HCID 229862MLS000738021Yield 71.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g of 2-amino-4,6-dichloropyrimidine are suspended in 100 ml of ethanol. 11.15 g of butylamine are added. The reaction mixture is refluxed for 2 hours and then evaporated to dryness. The residue is taken up in 100 ml of water. After 1 hour's stirring the precipitate is filtered off on sintered glass and is then recrystallized from 80 ml of 6/4 water/acetonitrile. 8.75 g of 2-amino-4-butylamino-6-chloropyrimidine are obtained.

Workup

  1. temperatureThe reaction mixture is refluxed for 2 hours
  2. customevaporated to dryness
  3. filtrationis filtered off on sintered glass
  4. customis then recrystallized from 80 ml of 6/4 water/acetonitrile

Sources & evidence

ORD record
ord-eab0454af4b841da9a5e016277412805
Source dataset
uspto-grants-1998_06
Patent number
US05772990

Reaction notes

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