反应详情

10 g of 2-amino-4,6-dichloropyrimidine are suspended in 100 ml of ethanol. 20.8 g of ethylamine are added as 33% solution in water. The reaction mixture is refluxed for 2 hours and is then evaporated to dryness. The precipitate obtained is taken up in 100 ml of water. After 1 hour's stirring, the mixture is filtered on sintered glass. The precipitate is recrystallized from 25 ml of acetonitrile. 8.10 g of 2-amino-4-ethylamino-6-chloropyrimidine are obtained.

1. temperatureThe reaction mixture is refluxed for 2 hours
2. customis then evaporated to dryness
3. customThe precipitate obtained
4. filtrationthe mixture is filtered on sintered glass
5. customThe precipitate is recrystallized from 25 ml of acetonitrile