反应详情

A suspension of compound 3 (20 g) in dry methanol:dichloromethane (2:1, 400 ml) containing sodium methoxide in methanol (0.46 g. Na in 100 ml of methanol) was stirred at room temperature until starting product disappeared (tlc). The solution was then made neutral with mixed-bed resin (50 ml, BioRad AG501-X8), filtered and evaporated to dryness to give 4 (10.2 g, 76%).

1. filtrationfiltered
2. customevaporated to dryness