2-Propenoic acid, 3-(4-formylphenyl)- → 3-(4-Formylphenyl)propanoic acid

HRID 964879노트

반응식

HRID 964879 반응식
[CH:1]([C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)=[O:2].C(C1C=CC(C(C)C(O)=O)=CC=1)=O>CO.[Pt]=O>[CH:1]([C:3]1[CH:13]=[CH:12][C:6]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)=[O:2]

참가 물질

5

반응물 2

HCID 980772-Propenoic acid, 3-(4-formylphenyl)-HCID 102196632-(4-Formylphenyl)propionic acid

생성물 1

HCID 198252413-(4-Formylphenyl)propanoic acid

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

A mixture of 253 mg (1.44 mmol) of 4-formylcinnamic acid and 32.61 mg of platinum oxide in 10 mL of methanol is stirred overnight at room temperature under an atmosphere of hydrogen supplied by a balloon. The mixture is filtered through celite and concentrated in vacuo. The residue is dissolved in 0.1N sodium hydroxide solution and washed with ether. The aqueous layer is then acidified and the product is extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride solution and dried over magnesium sulfate. The solvent is removed in vacuo to afford an inseparable mixture of 4-formylphenylpropanoic acid and other reduction products. The mixture is utilized in the next reaction without characterization or further purification.

후처리

  1. filtrationThe mixture is filtered through celite and
  2. concentrationconcentrated in vacuo
  3. dissolutionThe residue is dissolved in 0.1N sodium hydroxide solution
  4. washwashed with ether
  5. extractionthe product is extracted with ethyl acetate
  6. washThe organic layer is washed with saturated sodium chloride solution
  7. dry with materialdried over magnesium sulfate
  8. customThe solvent is removed in vacuo
  9. customto afford
  10. customThe mixture is utilized in the next reaction without characterization or further purification

출처 및 근거

ORD 기록
ord-b28d3d43d97b4c4ca351bb52bb20e0e1
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05773001

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