Acetic Anhydride → HCID 53999224, compound

HRID 964915Notes

Reaction equation

HRID 964915 reaction equation
[Cl:1][C:2]([F:16])([F:15])[C:3](=[O:14])[CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=[O:6].[CH:17]([O-])([O-])[O:18][CH2:19][CH3:20].C(OC(=O)C)(=O)C>>[Cl:1][C:2]([F:15])([F:16])[C:3](=[O:14])[C:4](=[CH:17][O:18][CH2:19][CH3:20])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=[O:6]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 15338017HCID 15338017, compoundHCID 53630039Ethylorthoformate

Product 1

HCID 53999224HCID 53999224, compoundYield 100.8%

Procedure

A mixture of 49.5 g of 1-choro-4-(4-chlorophenyl)-1,1-difluoro-2,4-butanedione, 41.3 g of ethyl orthoformate and 57 g of acetic anhydride was refluxed under heating for 4 days. The solvent was distilled off to obtain 60.4 g of the crude product, which was used for the next reaction directly.

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 4 days
  3. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-19c1e5e557f440598cd4f9b82d0a2fe6
Source dataset
uspto-grants-1998_06
Patent number
US05773388

Reaction notes

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