Acetic Anhydride → HCID 53904376, compound

HRID 964918Notes

Reaction equation

HRID 964918 reaction equation
[Cl:1][C:2]([F:15])([F:14])[C:3](=[O:13])[CH2:4][C:5]([CH:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:6].[CH:16]([O-])([O-])[O:17][CH2:18][CH3:19].C(OC(=O)C)(=O)C>>[Cl:1][C:2]([F:14])([F:15])[C:3](=[O:13])[C:4](=[CH:16][O:17][CH2:18][CH3:19])[C:5]([CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1)=[O:6]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 19074104HCID 19074104, compoundHCID 53630039Ethylorthoformate

Product 1

HCID 53904376HCID 53904376, compoundYield 96.2%

Procedure

A mixture of 235.9 g of 1-chloro-4-cyclohexyl-1,1-difluoro-2,4-butanedione, 266.4 g of ethyl orthoformate and 367.2 g of acetic anhydride was refluxed under heating for 12 hours. The solvent was distilled off under reduced pressure to obtain 280.3 g of the desired product (crude product), which was directly used for the next reaction. A part of the crude product was further purified for measurement of the refractive index. nD20.6 1.4787

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 12 hours
  3. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-24c4d671e851493188aada8d55c6ebb1
Source dataset
uspto-grants-1998_06
Patent number
US05773388

Reaction notes

Loading…