Methyl chloroformate → Methyl 5-methylthiophene-3-carboxylate

Participants

Reaction Steps

Alternatively, initial lithiation of 3-bromo-5-methylthiophene followed by capture with methyl chloroformate gives methyl 5-methylthiophene-3-carboxylate. Free-radical bromination of the methyl group followed by treatment with an alkali azide, subsequent reduction and hydrolysis provides 5-(aminomethyl)thiophene-3-carboxylic acid (VI). ##STR38##

Provenance & Evidence