Hydrochloric Acid → HCID 19074975, compound

Participants

Reaction Conditions

Reaction Steps

1.5 g of methyl (RS)-4-(5-formyl-7,8-dimethoxy-2H-1-benzopyran-2-yl)-butyrate were dissolved in 10 ml of tetrahydrofuran under argon and then treated with 1 ml of 1N NaOH and stirred at 20° C. for 1.5 hrs. The reaction mixture was acidified with 9 ml of 1N HCl, saturated with NaCl and extracted with 2×20 ml of ethyl acetate. The crude product was chromatographed on silica gel in ethyl acetate and chromatographed from toluene/hexane 1:1 There was obtained (RS)-4-(5-formyl-7,8-dimethoxy-2H-1-benzopyran-2-yl)-butyric acid as white crystals.

Provenance & Evidence