反应详情

6-iodo-4-chloro-2-trichloromethyl-quinazolin (8.14 g, 20 mmol) was dissolved in ether (anhydrous 200 mL) under stirring at rt. To this solution 3-amino-1-ethyl-piperidine (2.56 g, 20 mmol) in ether (anhydrous 30 mL) was added at 0C. The reaction mixture was allowed to warm to rt overnight. Buff colored solid separated which was filtered, washed with ether (200 mL) and air dried. Crude yield: 5.1 g. The crude material was suspended in MeOH and stirred vigorously for 0.5 h and filtered. The solid was dried in vacuo (0.01 mm). Yield: 3.72 g, (34.7%). Mp 265°-266° C.

1. temperatureto warm to rt overnight
2. customseparated which
3. filtrationwas filtered
4. washwashed with ether (200 mL) and air
5. customdried
6. stirringstirred vigorously for 0.5 h
7. filtrationfiltered
8. customThe solid was dried in vacuo (0.01 mm)