Di-benzoyl-d-tartaric acid → HCID 131720733, compound

Participants

Reaction Steps

4.0 g of (+/-)-cis-diethyl 4-[4-(4-cyanophenyl)-1-piperazinyl]-1,3-piperidinediacetate and 3.4 g of (+)-dibenzoyl-D-tartaric acid were dissolved in 140 ml of a mixed solvent of ethyl acetate/diisopropyl ether (1/1) and subjected to resolving crystallization. The crystals obtained were recrystallized several times from a mixed solvent of ethyl acetate/diisopropyl ether (1/1), whereby was obtained 690 mg of (+)-cis-diethyl 4-[4-(4-cyanophenyl)-1-piperazinyl]-1,3-piperidinediacetate (+)-dibenzoyl-D-tartrate (98.4% e.e.).

Provenance & Evidence