dibenzoyl-L(+)tartaric acid → HCID 131720733, compound

Participants

Reaction Steps

6.3 g of (+/-)-cis-diethyl 4-[4-(4-cyanophenyl)-1-piperazinyl]-1,3-piperidinediacetate and 5.4 g of (-)-dibenzoyl-L-tartaric acid were dissolved in 180 ml of a mixed solvent of ethyl acetate/diisopropyl ether (1/1) and subjected to resolving crystallization. The crystals obtained were recrystallized several times from a mixed solvent of ethyl acetate/diisopropyl ether (1/1), whereby was obtained 640 mg of (-)-cis-diethyl 4-[4-(4-cyanophenyl)-1-piperazinyl]-1,3-piperidinediacetate (-)-dibenzoyl-D-tartrate (98.4% e.e.).

Provenance & Evidence