Hydrochloric Acid → HCID 67690311, compound

Participants

Reaction Steps

350 mg of ethyl 4-[4-(4-amidinophenyl)-1-piperazinyl]-1-ethoxycarbonylmethyl-3-piperidinepropionate hydrochloride was dissolved in 20 ml of ethanol, and 2.5 ml of an aqueous solution of 1N-sodium hydroxide was added thereto and stirred at room temperature for 5 hours. 2.5 ml of 1N-hydrochloric acid was added to the reaction liquid, from which the solvent was removed by distillation. The resulting residue was purified by HP-20 column chromatography (using a gradient eluent of water to water/ethanol=50/1) to obtain 180 mg of 4-[4-(4-amidinophenyl)-1-piperazinyl)-1-carboxymethyl-3-piperidinepropionic acid hydrochloride.

Provenance & Evidence