Trifluoroacetic acid → HCID 67690426, compound

Participants

Reaction Steps

0.45 g of methyl 4-[4-(4-amidinophenyl)-1-piperazinyl]-1-(tert-butoxycarbonylmethyl)-3-piperidinepropionate hydroiodide was dissolved in 50 ml of an aqueous solution of 90%-trifluoroacetic acid and stirred at room temperature for 15 minutes. The reaction mixture was concentrated, and the resulting residue was purified by HP-20 column chromatography (using an eluent of water/methanol=10/1) to obtain 0.32 g of 4-[4-(4-amidinophenyl)-1-piperazinyl]-3-methoxycarbonylethyl-1-piperidineacetic acid trifluoroacetate.

Provenance & Evidence