HCID 131720735, compound → HCID 131720738, compound

Participants

Reaction Steps

280 mg of (+)-cis-diethyl 4-[4-(4-amidinophenyl)-1-piperazinyl]-1,3-piperidinediacetate hydrochloride was dissolved in 10 ml of 1N-hydrochloric acid and refluxed for 48 hours. The reaction liquid was distilled, and the resulting residue was purified by ODS column chromatography (using an eluent of water) to obtain 160 mg of (+)-cis-4-[4-(4-amidinophenyl)-1-piperazinyl]-1,3-piperidinediacetic acid trihydrochloride (98.2% e.e.).

Provenance & Evidence