Methanol → HCID 19074876, compound

Participants

Reaction Steps

0.089 g of ethyl 4-[4-(4-amidinophenyl)-2,5-dioxo-1-piperazinyl]-1-piperidineacetate hydrochloride was dissolved in 1 ml of water, and 0.017 g of lithium hydroxide monohydrate was added thereto with cooling with ice. This was stirred for 30 minutes still with cooling with ice, and an aqueous saturated solution of ammonium chloride was added thereto. Next, this was subjected to ODS column chromatography (H2O→H2 O/MeOH=3/2, v/v) to obtain 0.027 g of 4-[4-(4-amidinophenyl)-2,5-dioxo-1-piperazinyl]-1-piperidineacetic acid.

Provenance & Evidence