反应详情

7-Methoxycarbonyl-4-chloroquinoline(3.75 g, 0.017 mol) was dissolved in methanol (200 ml), added under ice-cooling with sodium borohydride (12.9 g, 0.34 mol) and stirred for an hour. The reaction mixture was poured into ice water. The resulting precipitates were collected by filtration, dried over phosphorus pentoxide and recrystallized from chloroform (20 ml) to obtain 1.0 g (30%) of 7-hydroxymethyl-4-chloroquinoline.

1. additionadded under ice-
2. customThe resulting precipitates
3. filtrationwere collected by filtration
4. dry with materialdried over phosphorus pentoxide
5. customrecrystallized from chloroform (20 ml)