HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 19075318, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Butyn-1-ol | HCID 12991 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19075318 | HCID 19075318 | — |
Reaction Steps
To a solution of 2-butyn-1-ol (530 mg, 7.5 mmol) and sodiumhydride (180 mg, 7.5 mmol) in dry tetrahydrofuran was added a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)pyridine (490 mg, 2.5 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05773452 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-6500bb58c92646ff86536cd07a9f8168 |
| Source note | uspto-grants-1998_06 |