Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Butanethiol | HCID 8012 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 15180168 | HCID 15180168 | — |
Reaction Steps
To a solution of 1-butanethiol (2.7 g, 30 mmol) and sodium hydride (1.2 g, 30 mmol) in dry tetrahydrofuran was added a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)pyridine (1.2 g, 6 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at -10° C. for 0.5 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated. The residue was purified by column chromatography (SiO2, eluent: ethyl acetate/methylene chloride (1:1)) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05773452 |
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| Source dataset | uspto-grants-1998_06 |
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| ORD ID | ord-81d88899de3d4bcf83fa829793e5431c |
|---|
| Source note | uspto-grants-1998_06 |
|---|
